Custom Peptides
Cayman Chemical Isoursodeoxycholic Acid, Purity: ≥98%, CAS: 78919-26-3, 10 mg
An epimer of ursodeoxycholic acid; decreases serum ALP, AST, and ALT levels in bile duct-ligated rats at 2,500 mg/kg in the diet
Cayman Chemical 7-Chlorokynurenic Acid, Purity: ≥95%, CAS: 18000-24-3, 10 mg
A glycine-site selective NMDA receptor antagonist; selectively binds to the NMDA receptor glycine-binding site (IC50 = 0.56 µM) over the NMDA-, quisqualate-, and kainate-binding sites (IC50s = 169, 153, and >1,000 µM, respectively); induces antidepressant-like activity in a variety of behavioral tests in mice at 0.1 and 1 mg/kg
Cayman Chemical Voclosporin, Purity: ≥98%, CAS: 515814-01-4, 10 mg
An immunosuppressant; binds to cyclophilin A (Kd = 15 nM); inhibits calcineurin activity in isolated human whole blood (IC50 = 120 ng/ml); reduces the proliferation of, and production of IL-2, IFN-γ, and TNF-α in, isolated cynomolgus monkey lymphocytes (EC50s = 202.79, 135.32, 177.11, and 138.56 ng/ml, respectively); decreases disease severity in a rat model of IRBP-induced experimental autoimmune uveoretinitis from 2.5-40 mg/kg; increases graft survival in a rat model of heterotopic heart transplantation at 1.75 mg/kg; unlike cyclosporin A, it does not increase serum creatinine levels in rabbits; inhibits the replication of SARS-CoV-2 in infected Calu-3 cells
Cayman Chemical AM92016 (hydrochloride), Purity: ≥98%, CAS: 133229-11-5, 10 mg
An IKr inhibitor (IC50 = 40 nM in isolated rabbit sinoatrial node cells); selective for IKr over L-type Cav current and If at 1 µM; decreases the diastolic depolarization rate and increases cycle length and action potential duration at full repolarization in isolated rabbit sinoatrial node cells at 50 nM; decreases the QT interval and increases heart rate in anesthetized guinea pigs at 1 mg/kg; decreases the time to first arrhythmia and ventricular fibrillation in ouabain-stimulated guinea pigs at 1 mg/kg
Cayman Chemical 1,2-Dioleoyl-sn-glycero-3-EPC (chloride), Purity: ≥95%, CAS: 474945-24-9, 10 mg
A cationic esterized phospholipid; has been used in combination with other lipids in the formation of lipid bilayers
Cayman Chemical Levomedetomidine (hydrochloride), Purity: ≥98%, CAS: 190000-46-5, 10 mg
The levorotary enantiomer of medetomidine; reduces the level of dexmedetomidine-induced sedation in dogs
Cayman Chemical Norastemizole, Purity: ≥98%, CAS: 75970-99-9, 10 mg
A histamine H1 receptor antagonist and active metabolite of astemizole (IC50 = 4.1 nM); inhibits currents in a whole-cell patch-clamp assay using HEK293 cells expressing hERG (IC50 = 27.7 nM); prevents IL-1β-induced increases in the levels of ICAM-1 and VCAM-1 in HUVECs at 100 µM; inhibits passive cutaneous anaphylaxis induced by OVA or the histamine, but not by bradykinin, in guinea pigs at 1 mg/kg; inhibits eosinophil infiltration into the lungs of mice in a mouse model of OVA-induced asthma at 1 mg/kg
Cayman Chemical 2-Methoxymethamphetamine (hydrochloride), Purity: ≥98%, CAS: 5588-10-3, 10 mg
An analytical reference standard categorized as an amphetamine; has been found as an AAF during anti-doping testing; intended for research and forensic applications
Cayman Chemical JWH 018 2'-naphthyl-N-(1,2-dimethylpropyl) isomer, Purity: ≥98%, CAS: 1870862-08-0, 10 mg
Differs from JWH 018 structurally by having a 1,2-dimethylpropyl chain, rather than a pentyl chain, extending from the indole group and the naphthyl moiety attached at its 2 position
Cayman Chemical N-(2-Azidoethyl)betulonamide, Purity: ≥95%, CAS: 2055270-64-7, 10 mg
A pentacyclic triterpenoid intermediate; an intermediate in the synthesis of betulonic acid derivatives with in vitro cancer cell cytotoxicity
Cayman Chemical Brevifolincarboxylic Acid, Purity: ≥95%, CAS: 18490-95-4, 10 mg
A phenol with anticancer and anti-inflammatory activities; inhibits the proliferation of PC-14 lung cancer cells (IC50 = 3.95 µg/ml); reduces LPS-induced increases in NO production in RAW 264.7 macrophages at 20 µM
Cayman Chemical Dimethindene (maleate), Purity: ≥98%, CAS: 3614-69-5, 10 mg
A histamine H1 receptor antagonist (Ki = 1.5 nM); selective for histamine H1 receptors over M1 mAChRs and 5-HT receptor subtype 5-HT2A (Kis = 64 and 2,400 nM, respectively); alone or in combination with icodextrin decreases adhesions between the abdominal wall and intraperitoneal viscera and local vascularization following surgical-induced abdominal trauma in rabbits at 0.1 mg/kg
Cayman Chemical N-Allyl-(±)-SKF 38393 (hydrobromide), Purity: ≥98%, CAS: 300561-58-4, 10 mg
A dopamine D1 receptor partial agonist; selective for dopamine D1 over D2 receptors in radioligand binding assays (Kis = 302 and 5,250 nM, respectively); reduces food intake in rats (ED50 = 3.6 mg/kg); reduces cocaine and food self-administration in squirrel monkeys from 0.1-10 mg/kg
Cayman Chemical O-desmethyl Brinzolamide (hydrochloride), Purity: ≥98%, CAS: 2967475-56-3, 10 mg
An active metabolite of brinzolamide; inhibits CAII and CAIV (IC50s = 0.136 and 165 nM, respectively)
Cayman Chemical Curcumenol, Purity: ≥98%, CAS: 19431-84-6, 10 mg
A sesquiterpene; active against methicillin-resistant S. aureus (MRSA) and P. aeruginosa; cytotoxic to CEM-SS lymphoblastic leukemia cells (IC50 = 11.9 µg/ml); decreases cell viability of AGS human gastric carcinoma cells (IC50 = 263.34 µM)